منابع مشابه
Succinyl phosphate. Its nonenzymatic hydrolysis and reaction with coenzyme A.
Succinyl phosphate reacts rapidly and nonenzymatically with coenzyme A in the pH range 3 to 8 to yield succinyl coenzyme A. This hitherto unsuspected reaction of an acyl phosphate with a thiol depends critically on the presence within the molecule of a free carboxyl group, which bears a “succinyl” relationship-and is spatially accessible-to the phosphorylated carboxyl. The free carboxyl group i...
متن کاملEvaluation of succinyl neocarzinostatin in vivo.
The toxicity of the bis-succinyl derivative of the protein antibiotic, neocarzinostatin, was compared with the parent compound, neocarzinostatin (NCS), in rats. The derivative was found to be about two to five fold more active than NCS in vivo. The antitumor activity in rats bearing eleven distinct Yoshida hepatoma ascitic cell lines was tested under four possible combinations with regard to si...
متن کاملThe Crystal Structure of Succinyl-CoA Synthetase
The x-ray crystal structure of succinyl-CoA synthetase (SCS) from Escherichia coli has been determined by the method of mu!tiple isomorphous replacement to a resolution of 2.5 A. Crystals of SCS are tetragonal with a space group of P4,22 oand unit cell dimensions of a = b = 98.47 A and c = 400.6 A. One molecule of SCS (142 kDa) is contained in the asymmetric unit. The current model has been ref...
متن کاملN-succinyl chitosan–dialdehyde starch hybrid hydrogels for biomedical applications
A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff's base reaction between amine groups of SCS and dialdehyde groups of DAS to form -CH 000000000000 000000000000...
متن کاملSuccinyl-CoA Synthetase: New Antigen Candidate of Bartonella bacilliformis
BACKGROUND Bartonella bacilliformis is the causative agent of Carrion's disease, a neglected illness with mortality rates of 40-85% in the absence of treatment. The lack of a diagnostic technique to overcome misdiagnosis and treat asymptomatic carriers is of note. This study aimed to identify new B. bacilliformis antigenic candidates that could lead to a new diagnostic tool able to be implement...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62710-3